|
KMID : 0606920080160010040
|
|
Biomolecules & Therapeutics
2008 Volume.16 No. 1 p.40 ~ p.45
|
|
|
Toxicity of Aceporol 330 in Mice as Novel Solubilizer of Paclitaxel
|
|
Kim Yeo-Woon
Chung Kyu-Nung
Kang Hoon-Suk
Sheen Yhun-Yhong
|
|
|
Abstract
|
|
|
|
The objective of this study was to investigate the single dose and 2-week repeated dose toxicity of Aceporol 330 in ICR mice following single intravenous administration and to compare its toxicity with a commercially available solubilizer of paclitaxel, Cremophor EL. In single dose toxicity test, LD50 of Aceporol 330 in mice was estimated to be greater than maximum applicable dose, 4 ml/kg. However, LD50 of Cremophor EL in male mice was determined to be 4 ml/kg. Maximum tolerated dose (MTD) of males and females in Aceporol 330-treated group and MTD of females in Cremophor EL-treated group were 3 ml/kg. MTD of males in Cremophor EL-treated group was less than 3 ml/kg. Characteristic toxic symptoms, and hematological and blood chemical changes were not observed after single dose and repeated dose of Aceporol 330 or Cremophor EL. No histopathological abnormalities were found in organs of all animal groups. Based on the linear pharmacokinetic property of paclitaxel and the higher LD50in mice, Aceporol 330 has a potential for use as a safer solubilizer for paclitaxel than Cremophor EL.
|
|
|
KEYWORD
|
|
|
Aceporol 330, Cremophor EL, toxicity, mice
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|